Cyclodextrins include natural cyclodextrins (α-cyclodextrin β-cyclodextrin, γ-cyclodextrin), modified derivatives of cyclodextrins (hydroxypropyl-β-cyclodextrin, hydroxypropyl-γ-cyclodextrin, betadex sulfobutyl ether sodium, methyl-β-cyclodextrin, etc.), all of which have a hydrophilic outer cavity and a hydrophobic inner cavity.The combination with drug molecules can usually form complex, which plays the role of slow release, reducing irritation and increasing bioavailability. With the deepening of research on cyclodextrin in recent years, its pathology and toxicology have been well understood.
A combination of corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics is commonly used to treat or prevent conditions such as eye fatigue, such as eye inflammation or infection that may occur after eye surgery.
Corticosteroids are the most commonly used treatment for ophthalmology.Corticosteroids are synthetic drugs that mimic the body's naturally produced steroid hormones.These steroid hormones have multiple roles and control functions in several important physiological systems, including stress response, immune response, inflammatory response, carbohydrate metabolism, protein catabolism, and blood electrolyte levels.But corticosteroids still carry a number of potential risks and side effects.
The advantage of non-steroidal anti-inflammatory drugs is that in addition to their anti-inflammatory effects, they also have analgesic effects.In addition, NSAIDs inhibit pupil constriction (pupil constriction), which is very useful during eye surgery.NSAIDs are often used to prevent and treat macular cystic edema (CME) after eye surgery.
Antibiotics is the most commonly used counter drugs including antibiotics and for the effect of moxifloxacin, ciprofloxacin, ofloxacin, levofloxacin, bei length, fluoroquinolone, etc., for the treatment of bacterial infections has a very high effect, but the years have some side effects of long-term use of antibiotics, as a result, reduce the use of antibiotics, become a consistent conclusion in medical science.
By combining corticosteroids, NSAIDs, antibiotics, and cyclodextrins in varying proportions, it is possible to replace the need to prescribe several drugs at a time with the need for only one drug, reduce eye irritation, increase bioavailability, and reduce the side effects of a single drug. Cyclodextrin and these drugs constitute a golden partner, in the future this aspect of the study will certainly be more and more, so that more patients with eye diseases benefit.