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Hydroxypropyl betadex inclusion of resveratrol improves activity value

Hydroxypropyl beta cyclodextrin CAS No.: 128446-35-5  can include many unstable active molecules, while protecting its active ingredients, it can also delay the release and improve bioavailability.

Resveratrol (RES), a non-flavonoid polyphenol compound, is mainly found in plants such as peanuts, grapes, and knotweed. Studies have shown that RES has a wide range of pharmacological effects, including immune regulation, anti-tumor, anti-inflammatory, anti-viral, and cardiovascular protection. RES belongs to the Biopharmaceutical Classification System (BCS) II drug. It is easily soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide, but its solubility in water is extremely low, only 30 ug/mL, and it is optically unstable. Sex. Due to the poor water solubility, unstable properties and low bioavailability of RES, its clinical application is limited.

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Hydroxypropyl beta cyclodextrin (HPBCD) is a product produced by the etherification reaction of the hydroxyl group on Beta CD glucose residues into the hydroxypropyl group, and its water solubility is relatively large. Embedding resveratrol with cyclodextrin makes up for the poor solubility of resveratrol in water, is easily oxidized by oxidants and is easily degraded by light, and also improves the biological activity and medicinal value of resveratrol.

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