Products using SBECD in marketed drugs (2) posaconazole

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Products using SBECD in marketed drugs (2) posaconazole

Posaconazole is a derivative of itraconazole, a second-generation triazole antifungal drug marketed in 2006 by the FDA. The trade name is NOXAFIL, and the original manufacturer is Schering-Plough.

In 2014, the FDA approved Merck’s posaconazole injection dosage form, with an injection specification of 300 mg/bottle.

Posaconazole has broad-spectrum activity as an antifungal agent. In vitro and in vivo experiments have proved that posaconazole has excellent anti-Candida (including Candida albicans Candida subglabrata, and Candida tropicalis) activity, and also has resistance to other opportunistic pathogenic fungi and opportunistic Candida As well as the activity of Chromosporium and dermatophytes, in which opportunistic pathogenic fungi include but are not limited to Aspergillus, Clostridium, Basidiomycetes, Odontophytes, Coccidioides macrosporum, Histoplasma, Zygomycetes and Actinomycetes of the foot.

CAS No.: 171228-49-2

Molecular formula: C37H42F2N8O4

Molecular weight: 700.77700

The molar ratio of posaconazole and sulfobutyl beta cyclodextrin is 1:7.2, and the weight ratio is 1:22.26. 300 mg posaconazole injection is equipped with 6680 mg sulfobutyl beta cyclodextrin sodium.

The patent validity of posaconazole for injection is 2032 (US 13/704,145)

Shandong Binzhou Zhiyuan Biological Technology Co., Ltd. is committed to professional production of pharmaceutical excipients:

·Betadex sulfobutyl ether sodium , DMF NO.: 030167  (injection grade /USP standard/remdesivir material

·Hydroxypropyl  betadex, DMF NO.: 030168   (pharm grade / cosmetics grade / technical grade)

·Methyl beta cyclodextrin - CAS No.128446-36-6

·Other customized cyclodextrin derivatives/reagents/complexes/polymers. 

Zhiyuan Biotech sincerely looks forward to cooperate with you for a better future.


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