The main role of sulfobutyl beta cyclodextrin sodium in the field of medicine

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The main role of sulfobutyl beta cyclodextrin sodium in the field of medicine

Cyclodextrin has a special ring-shaped hollow cylindrical structure with a hydrophobic inner layer and a hydrophilic appearance. Cyclodextrin and its derivatives inclusion drugs are mainly polypeptide and protein hormones, such as glucagon, salmon calcitonin, corticotropin analogs, insulin, peptide relin, and luteinizing hormone releasing hormone.

The main advantage of negatively charged sulfobutyl beta cyclodextrin sodium as a new type of pharmaceutical excipients: because betadex sulfobutyl ether sodium has negatively charged branched chains, it has Nitrogen drugs have special affinity and inclusion properties, which can better increase the solubility and stability of the drug, increase the bioavailability of the drug, improve the release rate of the drug, reduce the irritation of the drug to local tissues, and reduce the volatility of the drug , Reduce toxic and side effects, cover up bad smell, reduce nephrotoxicity, etc.

When sulfobutyl beta cyclodextrin sodium is applied to injection drugs, the main function is to improve the solubility of poorly soluble drugs, so that the drugs can be delivered quickly and reach the required dose during injection, and reduce the impact of injection on the site of administration. It is irritating, improves the stability of the drug in the solution state, eases the hemolysis of the drug, and improves the safety of the drug.

At present, sulfobutyl beta cyclodextrin sodium is widely used in injection medicine, oral medicine, nasal medicine, eye medicine and other fields.

The main role of sulfobutyl beta cyclodextrin sodium in the field of medicine

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