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What is the Structure of Cyclodextrin and its Application Prospects?

Mar. 02, 2021

As a Methyl Beta Cyclodextrin Exporter, let me share with you.

Cyclodextrin is a general term for cyclic oligosaccharides formed from 6 or more glucopyranose molecules, which are produced by the action of cyclodextrin glucosyltransferase on starch. Common cyclodextrins include α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. The number of glucopyranose molecules that make up them is 6, 7, and 8. They can be separated by precipitation with organic solvents. Cyclodextrin is easily hydrolyzed under acidic conditions.

Methyl Beta Cyclodextrin

Methyl Beta Cyclodextrin

The molecular shape of cyclodextrin is like a tire. The secondary hydroxyl groups on the C-2 and C-3 atoms of each glucose residue are located at one end of the cyclodextrin ring molecule, and the diameter is slightly larger, while the primary hydroxyl group on C-6 Located at the other end, with a slightly smaller diameter. The inside of the cyclodextrin molecule is a "V"-shaped hydrophobic cavity with an inner diameter of 0.5 to 1.0 nm, which can include benzene rings and the like to form a complex.

Cyclodextrin is used in food, fragrance, medicine, compound resolution, etc., and it is also used in simulated enzyme research. It can also be used as an induction enhancer for nuclear magnetic resonance shift reagents.

Due to the small voids of α-CD molecules, it usually can only include guest substances of smaller molecules, and the application range is small; the molecular holes of γ-CD are large, but its production cost is high, and it cannot be mass-produced in industry. Limitations: β-CD has moderate molecular holes, a wide range of applications, and low production costs. It is the most used cyclodextrin product in the industry. However, the hydrophobic region and catalytic activity of β-CD are limited, which limits its application. In order to overcome the shortcomings of cyclodextrin itself, researchers tried to modify the precursor of cyclodextrin in different ways to change the properties of cyclodextrin and expand its application range. The so-called modification refers to the introduction of modified groups while keeping the basic skeleton of the cyclodextrin macrocycle unchanged to obtain products with different properties or functions. Therefore, it is also called modification. The modified cyclodextrin is also called cyclodextrin. Fine derivatives. At present, the method of cyclodextrin modification is mainly chemical method. Chemical modification is to use the alcohol hydroxyl group on the outer surface of the cyclodextrin molecule hole to carry out etherification, esterification, oxidation, crosslinking and other chemical reactions, which can make the cyclodextrin There are new functional groups on the outer surface of the molecular hole. The degree of reaction is expressed by the degree of substitution, that is, the number of substituted hydroxyl groups per glucose unit. For example: sulfobutyl beta cyclodextrin sodium, hydroxypropyl beta cyclodextrin, Methyl Beta Cyclodextrin, hydroxypropyl gamma cyclodextrin and so on.

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